AKG
TL;DR
Key intermediate in the Krebs cycle. Animal studies showed significant lifespan extension. Rejuvant LifeAKG human trial suggested biological age reversal via DNA methylation clocks, but remains controversial.
Safety: Well-tolerated. Generally well-tolerated. Mild GI discomfort. Natural metabolite in the body.
Cost: approximately $40-60/month.
What the research says
Krebs cycle intermediate with theoretical neuroprotective effects. Rejuvant trial measured biological age, not cognitive outcomes. Very limited data.
Cellular energy metabolism support. Limited direct metabolic endpoint data.
AKG on Amazon
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Safety & practical info
Generally well-tolerated. Mild GI discomfort. Natural metabolite in the body.
No significant drug interactions documented.
Branded CaAKG (Rejuvant) is expensive. Generic forms cheaper.
Sources for this page include published meta-analyses, systematic reviews, and NIH dietary supplement fact sheets. All claims reflect the evidence as of early 2026.
This is not medical advice. Consult your healthcare provider before starting any supplement, especially if you take medications.