Apigenin

4',5,7-trihydroxyflavone

Also known as: 4',5,7-trihydroxyflavone

SleepInflammation

TL;DR

A flavonoid found in chamomile, parsley, and celery. Binds to GABA receptors as a mild sedative. Also inhibits CD38, an NAD+-consuming enzyme. Popularized by Andrew Huberman for sleep onset.
Safety: Well-tolerated. Found naturally in common foods. Some concern about estrogenic effects at very high doses in animal studies.
Cost: approximately $10-15/month.
Best for: Sleep

What the research says

SleepModerate

Evidence

2/5

Onset speed

4/5

Typical dose: 50-100 mg before bed

Mostly mechanistic and animal data. Well-characterized GABA receptor binding. Human evidence largely extrapolated from chamomile extract studies. Popularized but under-studied as isolated compound.

Apigenin on Amazon

$10-15/mo (estimated)

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Safety & practical info

Safety:Well-tolerated

Found naturally in common foods. Some concern about estrogenic effects at very high doses in animal studies.

Interactions:Blood thinners, sedatives

Inhibits CYP1A2 and CYP2C9. May interact with anticoagulants and sedative medications.

Cost:$10-15/mo

Affordable at standard doses.

Sources for this page include published meta-analyses, systematic reviews, and NIH dietary supplement fact sheets. All claims reflect the evidence as of early 2026.

This is not medical advice. Consult your healthcare provider before starting any supplement, especially if you take medications.

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