Garlic
Content by: OpenSupplement Editorial Team | Medical review: pending | Last updated: April 13, 2026
TL;DR
Potent medicinal bulb containing the active compound allicin
High evidence for reducing blood pressure and supporting heart health
Moderate evidence for metabolic syndrome (lipids)
Acts as a mild natural ACE inhibitor and anti-clotting agent
Safe but can cause 'garlic breath' and GI upset
Very cheap: ~$5-12/month
Best for: High blood pressure, heart health maintenance
What it is
Garlic has been used as a medicine for over 5,000 years. When garlic is crushed or chopped, it releases allicin, a sulfur compound that gives garlic its smell and its health benefits. Allicin is unstable, so most supplements are designed to release it in the gut.
Garlic works like a 'mini-pharmacy.' It has anti-microbial, anti-clotting, and anti-hypertensive properties. It helps blood vessels relax (vasodilation) and prevents cholesterol from building up in the arterial walls.
What the research says
Garlic is a powerhouse for the heart. Blood Pressure. A 2020 meta-analysis of 12 trials found that garlic supplements reduced systolic blood pressure by an average of 8 mmHg, which is comparable to many blood pressure medications. Plaque. It has been shown to slow the progression of coronary artery calcification (plaque buildup). Evidence. The data for blood pressure is robust and consistent. [1][2][3]
Garlic is a great lipid 'balancer.' Cholesterol. It can lower total and LDL cholesterol by 10-15%. Blood Sugar. Some trials show a modest reduction in fasting glucose. While not a primary diabetes treatment, it's a perfect 'heart-healthy' addition for anyone with metabolic syndrome.
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Garlic on Amazon
Safety
Very safe. The biggest 'side effect' is body and breath odor. It can cause mild heartburn or flatulence. Because it thins the blood, it should be stopped 1-2 weeks before surgery.
Interactions
- Blood Thinners: Significant interaction with Warfarin, Clopidogrel, or Aspirin; increases bleeding risk.
- HIV Meds: May reduce the effectiveness of certain protease inhibitors (e.g., Saquinavir).
Dosing
Standard Dose: 600-1,200 mg of garlic powder daily (standardized to allicin). Form: Enteric-coated tablets help prevent 'garlic breath' and ensure allicin is released in the small intestine.
Cost
Dirt cheap. $5-12 per month.
The bottom line
Garlic is one of the most effective 'food' supplements in existence. If you have high blood pressure, it should be near the top of your list.
References
- Ried K, Frank OR, Stocks NP. Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension: a randomised controlled trial. Maturitas. 2010;67(2):144-50.
- Rohner A, Ried K, Sobenin IA, et al. A systematic review and metaanalysis on the effects of garlic preparations on blood pressure in individuals with hypertension. Am J Hypertens. 2015;28(3):414-23.
- Ried K, Toben C, Fakler P. Effect of garlic on serum lipids: an updated meta-analysis. Nutr Rev. 2013;71(5):282-99.
Sources for this page include published meta-analyses, systematic reviews, and NIH dietary supplement fact sheets. All claims reflect the evidence as of early 2026.
This is not medical advice. Consult your healthcare provider before starting any supplement, especially if you take medications.