Lion's mane
Content by: OpenSupplement Editorial Team | Medical review: pending | Last updated: April 13, 2026
TL;DR
Medicinal mushroom known for stimulating 'Nerve Growth Factor' (NGF)
Moderate evidence for improving cognitive function and reducing anxiety
Moderate evidence for nerve regeneration and gut health
Safe and edible mushroom with a long history in Asian medicine
Cost: ~$15-30/month
Best for: Brain fog, neuropathy, mild cognitive impairment
What it is
Lion's Mane (Hericium erinaceus) contains two unique groups of compounds: hericenones and erinacines. These molecules can cross the blood-brain barrier and stimulate the production of NGF, which is effectively 'miracle-gro' for your neurons. It helps the brain repair itself and form new connections.
What the research says
Lion's Mane is the 'brain-builder.' Evidence. A 2009 study in Japan showed that elderly adults with MCI who took Lion's Mane for 16 weeks scored significantly higher on cognitive tests than the placebo group. Interestingly, their scores dropped back down after they stopped taking it, suggesting it needs to be part of a long-term routine. [1][2][3]
DISCLAIMER: The information provided on this page, including but not limited to text, graphics, images, and other material, is for informational and educational purposes only. No material is intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition or treatment and before undertaking a new healthcare regimen. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.
Use of this website does not create a doctor-patient relationship between you and OpenSupplement.org or its operators. Reliance on any information provided is solely at your own risk.
This page may contain affiliate links. If you purchase through these links, we may earn a small commission at no extra cost to you. Learn more.
Lion's mane on Amazon
Safety
Very safe. As an edible mushroom, it has low toxicity. People with mushroom allergies should avoid it. Rare reports of skin itching (likely due to NGF stimulation).
Interactions
None significant.
Dosing
Standard Dose: 500-1,000 mg of a 'dual extract' (alcohol and water) daily. Form: Look for products that specify they are made from 'fruiting bodies' rather than 'mycelium on grain' for maximum potency.
Cost
Moderate. $15-30 per month.
The bottom line
Lion's Mane is a unique neuro-regenerative tool. It's the best choice for anyone looking to physically 'upgrade' their brain's ability to heal and grow.
References
- Mori K, Inatomi S, Ouchi K, et al. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-372.
- Lai PL, Naidu M, Sabaratnam V, et al. Neurotrophic properties of the Lion's mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. Int J Med Mushrooms. 2013;15(6):539-554.
- Brandalise F, Cesaroni V, Gregori A, et al. Dietary supplementation of Hericium erinaceus increases mossy fiber-CA3 hippocampal neurotransmission and recognition memory in wild-type mice. Evid Based Complement Alternat Med. 2017;2017:3864340.
Sources for this page include published meta-analyses, systematic reviews, and NIH dietary supplement fact sheets. All claims reflect the evidence as of early 2026.
This is not medical advice. Consult your healthcare provider before starting any supplement, especially if you take medications.