Lycopene
Content by: OpenSupplement Editorial Team | Medical review: pending | Last updated: April 13, 2026
TL;DR
Powerful antioxidant carotenoid found primarily in tomatoes
Observational studies suggest benefits for prostate and heart health
Better absorbed from cooked tomato products than raw tomatoes
Very safe with minimal side effects even at high doses
May work synergistically with other antioxidants
Best for: Men over 40, cardiovascular health support
What it is
Lycopene is a carotenoid antioxidant responsible for the red color in tomatoes, watermelon, pink grapefruit, and other red fruits. Unlike some carotenoids, lycopene cannot be converted to vitamin A in the body, but it has potent antioxidant properties that may protect against oxidative stress and inflammation.
Interestingly, lycopene is better absorbed from processed tomato products (like tomato sauce or paste) than from raw tomatoes, due to the breakdown of cell walls during cooking. Supplements typically provide lycopene in concentrations much higher than achievable through diet alone.
What the research says
Observational Evidence: Large epidemiological studies consistently show associations between higher lycopene intake and reduced cardiovascular disease risk. The Health Professionals Follow-up Study found men with highest lycopene intake had 21% lower risk of heart disease.
Clinical Trials: Smaller RCTs have shown mixed results. Some studies found lycopene supplementation improved cholesterol profiles and reduced blood pressure, while others showed no significant effects. A 2017 meta-analysis suggested modest benefits for cardiovascular risk factors, but noted study quality was variable.
Mechanism: Lycopene may protect LDL cholesterol from oxidation and reduce arterial inflammation, both key factors in atherosclerosis development. [1][2]
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Lycopene on Amazon
Safety
Lycopene is extremely safe with virtually no reported adverse effects in clinical studies. The only notable side effect is lycopenodermia—a harmless orange-red discoloration of the skin that can occur with very high intakes (typically over 30mg daily). This condition is reversible and purely cosmetic. Lycopene has been safely consumed by humans through food for thousands of years.
Interactions
• No significant drug interactions reported • Fat-soluble absorption: Best absorbed when taken with dietary fats or oils • Cholesterol medications: May theoretically enhance cholesterol-lowering effects • Other antioxidants: Works synergistically with vitamins C and E • Generally safe to combine with other supplements
Dosing
Cardiovascular Health: 10-20mg daily with meals containing fat
General Antioxidant Support: 5-10mg daily
High-Dose Research: Some studies used 15-30mg daily
Food Sources: One cup of tomato sauce provides about 25mg of lycopene
Cost
Lycopene supplements are moderately priced, typically costing $15-30 per month for quality products. Standardized extracts with guaranteed potency cost more than basic formulations. Getting lycopene from regular consumption of tomato products is very economical and may be just as effective as supplements.
The bottom line
Lycopene has solid observational evidence for cardiovascular and prostate health benefits, though clinical trial evidence is more mixed. It's extremely safe, relatively inexpensive, and can easily be obtained from cooked tomato products. While not a miracle supplement, lycopene appears to be a reasonable addition to an antioxidant-focused regimen, especially for men over 40 or those with cardiovascular risk factors.
References
- Cheng HM, Koutsidis G, Lodge JK, et al. Tomato and lycopene supplementation and cardiovascular risk factors: A systematic review and meta-analysis. Atherosclerosis. 2017;257:100-108.
- Jacques PF, Lyass A, Massaro JM, et al. Relationship of lycopene intake and consumption of tomato products to incident CVD. Br J Nutr. 2013;110(3):545-51.
Sources for this page include published meta-analyses, systematic reviews, and NIH dietary supplement fact sheets. All claims reflect the evidence as of early 2026.
This is not medical advice. Consult your healthcare provider before starting any supplement, especially if you take medications.