Nicotinamide riboside

Nicotinamide Riboside (NR)

Also known as: NR, TruNiagen, Niagen

CognitionHeart

TL;DR

Form of vitamin B3 that serves as NAD+ precursor. NAD+ levels decline with age. NR raises NAD+ effectively without niacin flushing. Whether NAD+ elevation translates to health benefits is the key question.
Safety: Well-tolerated. Well-tolerated up to 2000 mg. Some reports of mild nausea at high doses. Long-term safety data still accumulating.
Cost: approximately $70-120/month.

What the research says

Cognitive declineLow

Evidence

2.5/5

Onset speed

2/5

Typical dose: 300-1000 mg/day

NAD+ elevation confirmed in trials. Translation to cognitive outcomes unclear. Ongoing trials. Chromadex-funded research adds bias concerns.

Metabolic syndromeLow

Evidence

2/5

Onset speed

2/5

Typical dose: 300-1000 mg/day

Some evidence for improved mitochondrial function markers. Limited metabolic endpoint data.

Heart diseaseLow

Evidence

2/5

Onset speed

2/5

Typical dose: 300-1000 mg/day

NAD+ decline associated with cardiac aging. Limited interventional data for cardiovascular outcomes.

Nicotinamide riboside on Amazon

$70-120/mo (estimated)

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Safety & practical info

Safety:Well-tolerated

Well-tolerated up to 2000 mg. Some reports of mild nausea at high doses. Long-term safety data still accumulating.

Interactions:None significant

No significant drug interactions documented. Theoretical concern about NAD+ and cancer cell metabolism — no clinical evidence.

Cost:$70-120/mo

Premium pricing. TruNiagen at therapeutic doses is expensive.

Sources for this page include published meta-analyses, systematic reviews, and NIH dietary supplement fact sheets. All claims reflect the evidence as of early 2026.

This is not medical advice. Consult your healthcare provider before starting any supplement, especially if you take medications.

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