NMN

Nicotinamide Mononucleotide

Also known as: NMN, Beta-NMN

CognitionHeart

TL;DR

Another NAD+ precursor, popularized by David Sinclair. Debates NR vs NMN. Recent human trial from University of Washington showed improved muscle insulin sensitivity. Regulatory status has been uncertain.
Safety: Appears well-tolerated. Limited long-term safety data. Appears safe in completed trials. FDA regulatory status has fluctuated.
Cost: approximately $50-100/month.

What the research says

Cognitive declineLow

Evidence

2/5

Onset speed

2/5

Typical dose: 250-500 mg/day

Less human data than NR. University of Washington trial focused on metabolic outcomes. Cognitive data is very limited.

Metabolic syndromeLow

Evidence

2.5/5

Onset speed

2/5

Typical dose: 250-500 mg/day

University of Washington trial showed improved muscle insulin sensitivity in prediabetic women. Single study. More trials needed.

Heart diseaseLow

Evidence

2/5

Onset speed

2/5

Typical dose: 250-500 mg/day

Same theoretical rationale as NR. Very limited cardiovascular data.

NMN on Amazon

$50-100/mo (estimated)

See on Amazon →

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Safety & practical info

Safety:Appears well-tolerated

Limited long-term safety data. Appears safe in completed trials. FDA regulatory status has fluctuated.

Interactions:None significant

No documented drug interactions. Same theoretical concerns as NR regarding NAD+.

Cost:$50-100/mo

Premium pricing. Market has become more competitive but still expensive.

Sources for this page include published meta-analyses, systematic reviews, and NIH dietary supplement fact sheets. All claims reflect the evidence as of early 2026.

This is not medical advice. Consult your healthcare provider before starting any supplement, especially if you take medications.

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