PQQ
Content by: OpenSupplement Editorial Team | Medical review: pending | Last updated: April 13, 2026
TL;DR
Unique molecule (Pyrroloquinoline quinone) that stimulates 'mitochondrial biogenesis'
Moderate evidence for improving memory and processing speed
Moderate evidence for reducing inflammation and improving sleep
Synergizes exceptionally well with CoQ10
Relatively expensive: ~$25-40/month
Best for: Mitochondrial health, 'cellular aging' prevention
What it is
PQQ is a vitamin-like compound found in trace amounts in soil and some foods (like kiwi and green peppers). Its 'superpower' is its ability to trigger the growth of new mitochondria in aging cells. Since mitochondrial decline is a hallmark of aging, PQQ is a popular longevity supplement.
What the research says
PQQ is a 'neuro-regenerative' agent. Evidence. A double-blind trial showed that 20mg of PQQ improved memory and attention in middle-aged and elderly adults. The CoQ10 Combo. When PQQ is taken with CoQ10, the cognitive benefits are significantly amplified, as PQQ builds new mitochondria while CoQ10 helps the existing ones work better. [1]
Mitochondrial support may theoretically benefit cardiac energy production, but cardiovascular-specific human data is extremely limited. The Harris study [ref2] showed some mitochondrial metabolism changes, but direct cardiac outcomes remain unstudied. Currently more theoretical promise than proven cardiovascular benefit. [2][3]
DISCLAIMER: The information provided on this page, including but not limited to text, graphics, images, and other material, is for informational and educational purposes only. No material is intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition or treatment and before undertaking a new healthcare regimen. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.
Use of this website does not create a doctor-patient relationship between you and OpenSupplement.org or its operators. Reliance on any information provided is solely at your own risk.
This page may contain affiliate links. If you purchase through these links, we may earn a small commission at no extra cost to you. Learn more.
PQQ on Amazon
Safety
Generally safe at standard supplemental doses. Long-term human data is still accumulating, but current studies show no toxicity.
Interactions
None significant.
Dosing
Standard Dose: 10-20 mg daily. Timing: Take with a fat-containing meal.
Cost
Moderate-to-high. $25-40 per month.
The bottom line
PQQ is a high-tech longevity tool. If you are already taking CoQ10, adding PQQ is the logical next step for optimizing your cellular energy.
References
- Nakano M, Ubukata K, Yamamoto T, et al. Effect of pyrroloquinoline quinone (PQQ) on mental status of middle-aged and elderly persons. Food Style. 2009;13(7):50-3.
- Harris CB, Chowanadisai W, Mishchuk DO, et al. Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects. J Nutr Biochem. 2013;24(12):2076-84.
- Stites T, Storms D, Bauerly K, et al. Pyrroloquinoline quinone modulates mitochondrial quantity and function in mice. J Nutr. 2006;136(2):390-6.
Sources for this page include published meta-analyses, systematic reviews, and NIH dietary supplement fact sheets. All claims reflect the evidence as of early 2026.
This is not medical advice. Consult your healthcare provider before starting any supplement, especially if you take medications.