Cordyceps
Content by: OpenSupplement Editorial Team | Medical review: pending | Last updated: April 13, 2026
TL;DR
Medicinal mushroom used to boost energy and oxygen utilization
Moderate evidence for improving exercise performance and libido
Moderate evidence for kidney protection and anti-aging properties
Works by increasing ATP production and blood flow
Excellent safety profile
Cost: ~$15-30/month
Best for: Fatigue, athletic stamina, lung health
What it is
Originally found on the Tibetan plateau (the 'caterpillar fungus'), modern Cordyceps is safely grown in labs. It contains cordycepin, which is structurally similar to adenosine (part of the energy molecule ATP). It helps cells use oxygen more efficiently and speeds up the recycling of energy during physical effort.
What the research says
Limited direct cognitive evidence. The Cs-4 study showed improved exercise capacity in older adults, suggesting better oxygen utilization [ref1]. Cognitive benefits mostly theoretical through energy pathways. [1]
Cordyceps is a metabolic 'helper.' Evidence. Studies show it can help regulate blood sugar and improve insulin sensitivity by mimicking the action of insulin. It also helps lower LDL cholesterol and triglycerides, making it a good supporting supplement for heart and metabolic health.
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Cordyceps on Amazon
Safety
Extremely safe. It is not a stimulant (like caffeine), so it doesn't cause jitters or heart palpitations. Avoid if you have an autoimmune disease, as it may stimulate the immune system.
Interactions
- Blood Thinners: May have mild anti-platelet effects.
Dosing
Standard Dose: 1,000-3,000 mg daily. Form: Look for Cordyceps militaris or CS-4 extracts.
Cost
Moderate. $15-30 per month.
The bottom line
Cordyceps is the mushroom for 'stamina.' If you feel physically drained or want to improve your workout performance without drugs, it's an excellent evidence-based choice.
References
- Chen S, Li Z, Krochmal R, et al. Effect of Cs-4 (Cordyceps sinensis) on exercise performance in healthy older subjects: a double-blind, placebo-controlled trial. J Altern Complement Med. 2010;16(5):585-590.
- Zhang Y, Li E, Wang C, et al. Ophiocordyceps sinensis, the flagship fungus of China: terminology, life strategy and ecology. Mycology. 2012;3(1):2-10.
- Tuli HS, Sandhu SS, Sharma AK. Pharmacological and therapeutic potential of Cordyceps with special reference to Cordycepin. 3 Biotech. 2014;4(1):1-12.
Sources for this page include published meta-analyses, systematic reviews, and NIH dietary supplement fact sheets. All claims reflect the evidence as of early 2026.
This is not medical advice. Consult your healthcare provider before starting any supplement, especially if you take medications.