D-Mannose

Mannose

Also known as: Mannose

Kidney

TL;DR

Simple sugar that prevents E. coli from adhering to urinary tract walls. Used for UTI prevention. Does not affect blood sugar at therapeutic doses. Different mechanism than cranberry.
Safety: Excellent. Very well-tolerated. Does not affect blood sugar. Mild GI discomfort at high doses.
Cost: approximately $12-20/month.
Best for: Kidney disease

What the research says

Kidney diseaseHigh

Evidence

3.5/5

Onset speed

4/5

Typical dose: 2 g/day for prevention; 2g 3x/day acute

Multiple RCTs show comparable efficacy to low-dose antibiotics for UTI prevention. Mechanism is well-understood — blocks E. coli adhesion. Works quickly when taken early.

D-Mannose on Amazon

$12-20/mo (estimated)

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Safety & practical info

Safety:Excellent

Very well-tolerated. Does not affect blood sugar. Mild GI discomfort at high doses.

Interactions:None significant

No documented drug interactions.

Cost:$12-20/mo

Available as powder or capsules.

Sources for this page include published meta-analyses, systematic reviews, and NIH dietary supplement fact sheets. All claims reflect the evidence as of early 2026.

This is not medical advice. Consult your healthcare provider before starting any supplement, especially if you take medications.

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