Phosphatidylcholine
TL;DR
Major phospholipid in cell membranes and a source of choline. Supports liver cell membrane integrity and bile function. Polyenylphosphatidylcholine (PPC) form is most studied for liver.
Safety: Excellent. Very well-tolerated. GI discomfort rare. Found naturally in egg yolks and soybeans.
Cost: approximately $12-20/month.
Best for: Liver disease
What the research says
Multiple trials for alcoholic and non-alcoholic liver disease. Supports hepatocyte membrane repair. PPC form has the strongest evidence.
Choline source for acetylcholine production. Less efficient brain delivery than alpha-GPC or citicoline.
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Safety & practical info
Very well-tolerated. GI discomfort rare. Found naturally in egg yolks and soybeans.
No clinically meaningful drug interactions.
Affordable. Available from soy or sunflower sources.
Sources for this page include published meta-analyses, systematic reviews, and NIH dietary supplement fact sheets. All claims reflect the evidence as of early 2026.
This is not medical advice. Consult your healthcare provider before starting any supplement, especially if you take medications.