Liver conditions including NAFLD/MASLD, fatty liver, elevated enzymes, and general hepatoprotection.
Most widely used liver-protective herb. Silymarin is the active flavonolignan complex. Used historically for mushroom poisoning. Strong mechanistic evidence for hepatoprotection.
Precursor to glutathione, the body's master antioxidant. Originally a mucolytic drug, now used for liver protection (acetaminophen overdose antidote), respiratory health, and cochlear protection. One of the most versatile supplements.
Universal methyl donor involved in 200+ metabolic reactions. Prescription drug in Europe for depression and liver disease. Supports methylation, cartilage repair, and liver function.
Traditional Mediterranean remedy for liver and digestive health. Contains cynarin and chlorogenic acid. Evidence for cholesterol reduction and liver enzyme improvement.
Alkaloid from goldenseal and barberry. Activates AMPK, same pathway as metformin. Strong evidence for blood sugar and lipid management. Sometimes called 'nature's metformin.'
Active compound in turmeric with broad anti-inflammatory and antioxidant effects. Poor bioavailability requires enhanced formulations (piperine, phytosome, nanoparticle). One of the most researched natural compounds.
Major phospholipid in cell membranes and a source of choline. Supports liver cell membrane integrity and bile function. Polyenylphosphatidylcholine (PPC) form is most studied for liver.
Live beneficial bacteria. Effects are highly strain-specific — different strains do different things. Gut microbiome influences virtually every organ system. Quality and strain selection matter enormously.
Adaptogenic berry used in Traditional Chinese Medicine for 2,000+ years. Name means 'five-flavor berry.' Contains lignans (schisandrins) with hepatoprotective and cognitive-enhancing properties.
Most potent natural activator of Nrf2 pathway — the body's master antioxidant defense system. Derived from broccoli sprouts. Upregulates hundreds of protective genes.
Combination of probiotics and prebiotics in a single product. The prebiotic component feeds the probiotic strains, theoretically improving colonization and efficacy.
Adaptogenic herb from Ayurvedic medicine. Reduces cortisol, supports sleep, and may improve metabolic markers. KSM-66 and Sensoril are the most-studied standardized extracts.
Traditional herbal remedy for liver and kidney support. Root is used for liver/digestion; leaf as a natural diuretic. Limited but growing clinical evidence.
Concentrated polyphenol from green tea. EGCG is the primary active catechin. Supports metabolic rate, fat oxidation, and has neuroprotective properties. Liver safety concerns at high doses.
Mixture of phospholipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. Common food additive also used as a supplement. Source of choline and phospholipids.
Non-digestible fibers that feed beneficial gut bacteria. Inulin and FOS are the most common. Support gut microbiome diversity and short-chain fatty acid production.
One of the most revered medicinal mushrooms in Asian medicine. Contains triterpenes and polysaccharides. Traditionally used for calming, liver support, and immune modulation.
Blue-green microalgae with exceptional nutrient density. Rich in protein, B vitamins, iron, and phycocyanin (unique blue pigment with anti-inflammatory properties). One of the most nutrient-dense foods on Earth.
There are other evidence-based interventions studied for liver disease: