Schisandra
TL;DR
Adaptogenic berry used in Traditional Chinese Medicine for 2,000+ years. Name means 'five-flavor berry.' Contains lignans (schisandrins) with hepatoprotective and cognitive-enhancing properties.
Safety: Well-tolerated. GI discomfort, heartburn possible. May stimulate uterine contractions — avoid in pregnancy.
Cost: approximately $10-18/month.
Best for: Liver disease
What the research says
Several trials show reduced liver enzymes and improved liver function markers. Schisandrin B has specific hepatoprotective activity. Traditional use well-supported by modern research.
Adaptogenic effects may support cognitive function under stress. Limited direct cognitive trial data. Mostly based on traditional use and animal studies.
Schisandra on Amazon
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Safety & practical info
GI discomfort, heartburn possible. May stimulate uterine contractions — avoid in pregnancy.
Affects CYP3A4 and P-glycoprotein. May interact with cyclosporine, tacrolimus, and other CYP3A4 substrates.
Affordable standardized extract.
Sources for this page include published meta-analyses, systematic reviews, and NIH dietary supplement fact sheets. All claims reflect the evidence as of early 2026.
This is not medical advice. Consult your healthcare provider before starting any supplement, especially if you take medications.